Youjiale (levothyroxine sodium tablets) is widely used in substitution therapy of hypothyroidism, postoperative inhibitory therapy of thyroid cancer, adjuvant therapy of antithyroid drugs for hyperthyroidism, treatment of non-toxic goiter, etc.
This drug is very convenient to use, just take it once a day, but have you noticed several details?
Is it best to take medicine in what?
Youjiale should be given a one-day dose of clear water half an hour before breakfast.
Half an hour before breakfast may be difficult to grasp and easy to forget. It is recommended to take medicine immediately after getting up in the morning, then wash and so on, until the breakfast time is at least more than half an hour.
In this way, oily substances in gastrointestinal tract, wheat bran and the like can be prevented from affecting the absorption of drugs when taken together with food.
If you have difficulty taking the medicine in the morning, you can choose to take it 4 hours after dinner, that is, before going to bed. This can also try to avoid those factors that may affect drug absorption. Of course, if conditions permit, it is best to take the medicine half an hour before breakfast (this time can also be longer).
If taken with other drugs…
In clinical treatment, patients often need to use a combination of multiple drugs. These drugs may have mutual antagonism or synergistic effect. Taking them at the same time may not only affect the concentration of thyroxine, but also cause changes in absorption of other drugs in vivo. This situation requires additional attention when using Youjiale.
1. Drugs that affect the efficacy of eucarat
(1) If it is necessary to use medicinal charcoal and bile acid chelating agent (a lipid-lowering drug, such as coleenamine and coletipol) while using Youjiale, the medication should be carried out at intervals of more than 4-6 hours, which can help reduce the interaction between the two drugs.
(2) Gastric mucosal protective drug sucralfate, antacid drug aluminum hydroxide, proton pump inhibitor, iron and calcium supplement drugs (such as iron and calcium) can hinder the absorption of euthyroxine, and these drugs should be taken at least 2 hours later. Specific suggestions:
- Sucralfate and aluminum hydroxide should be taken 3-4 times a day. It is also required to take orally before meals. In order to avoid interaction, you can arrange to take Youjiale before going to bed. If you take it together with proton pump inhibitor for gastropathy, you should take it at intervals of more than 4 hours as much as possible. Calcium and iron usually only need to be taken once a day. When you take it together with Youjiale, you can take Youjiale orally on an empty stomach in the morning. Calcium and iron are arranged to take it before going to bed.
(3) Methadone, analgesic drug diacetamorphine, chemotherapy drug 5-fluorouracil, tamoxifen for breast cancer and ovarian cancer, anti-osteoporosis drug raloxifene, etc. can all delay the elimination of Youjiale. When combined with such drugs, the dosage of Youjiale can be appropriately reduced.
(4) Sleeping pills barbiturate, phenytoin sodium, carbamazepine for epilepsy treatment and trigeminal neuralgia treatment, anti-tuberculosis drug rifampicin, etc. can accelerate the metabolism of euthyroid, and when combined with such drugs, the dose of euthyroid can be appropriately increased.
2. Effects of Eujiale on other drugs
(1) It can enhance the anticoagulant effect of coumarin anticoagulants such as warfarin.
(2) To reduce the therapeutic effect and blood drug concentration of cardiac glycosides such as digoxin, the dosage of these drugs needs to be adjusted according to the situation.
(3) Taking Youjiale can also lead to an increase in blood sugar of diabetic patients and reduce the effect of hypoglycemic drugs. Therefore, diabetic patients should monitor blood sugar and adjust treatment in time when starting Youjiale treatment.
(4) Other drugs: Propylthiouracil for hyperthyroidism, Glucocorticoids, -Sympathetic drugs, Amiodarone for arrhythmia, Iodine-containing contrast agents and salicylates used in interventional therapy, sveram for the treatment of hyperphosphatemia in uremic patients, anti-tumor drugs imatinib and sunitinib, ritonavir, lopinavir, indinavir for the treatment of AIDS, high-dose furosemide, lipid-lowering drug antoin, antidepressant sertraline, chloroquine and chloroguanidine for the treatment of malaria, It can also affect the role of Youjiale.
Having said so many drugs, everyone may be confused. In order to facilitate everyone’s memory, the following points need to be paid attention to:
- Do not take Youjiale at the same time as any drug. If multiple drugs need to be used, Youjiale needs to be taken separately and other drugs should be used at intervals of several hours as far as possible. For long-term use of some drugs, attention should be paid to regular review of relevant disease indicators and thyroid function, and the dosage of previous drugs and euthyroid should be adjusted at any time according to the examination results. The simplest way is to ask or inform your doctor or pharmacist about the medicine you are currently taking, and let the doctor help you decide the treatment plan.
Other factors that may affect
Not only drugs, but also diseases and diet can affect the absorption of euthyroid.
The following diseases and foods can interfere with the absorption of euthyroid, and should be taken together with such foods as far as possible, or the dosage of euthyroid should be appropriately increased to ensure the curative effect:
- Diseases: chylus, liver cirrhosis, gastric acid deficiency and other absorption disorders syndrome; Food: grapefruit, soybean food, espresso, high fiber diet, etc.
A small piece of Youjiale looks inconspicuous, but it is still very important to take this drug correctly.
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It is recommended to take it on an empty stomach after getting up in the morning.
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Inform or ask a specialist or clinical pharmacist about other drugs you are using at the same time.
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Regular review of thyroid function and related diseases, by specialists according to the actual situation to adjust the dosage of drugs at any time.