Antibiotic-related diarrhea is not uncommon. Among patients treated with antibacterial drugs, The incidence rate ranges from 25% to 30%, and is more common when amoxicillin/clavulanic acid antibiotics (amoxicillin) are used. Antibiotic-related Clostridium difficile infection is also not uncommon, accounting for about 1/3 of antibiotic-related diarrhea patients. Clostridium difficile has now become a part of nosocomial infection. As over-the-counter drugs become more and more readily available, the use of probiotics has greatly increased. When patients are using antibacterial drugs, doctors even routinely recommend the use of probiotics to prevent antibiotic-related diarrhea. However, a large-scale study (PLACIDE study) found that there was no significant difference in the incidence of Clostridium difficile infection or antibiotic-related diarrhea between probiotic group and placebo group. Interestingly, Read More …