After continuous popular science, netizens now know that there are two kinds of antipyretic drugs widely used in the world, namely [acetaminophen] and [ibuprofen] recommended by the World Health Organization. Moreover, acetaminophen is the first choice of antipyretic due to its long clinical use time and high safety. Because acetaminophen has two different dosage forms, oral and suppository, netizens often ask me such questions: [acetaminophen can have suppository for rectal administration, why should there be oral dosage forms? Shouldn’t suppositories have less side effects than oral administration, and wouldn’t they hurt the liver? ] With this question in mind, let’s compare the absorption and metabolism differences between oral administration and suppository. Absorption and Metabolism of Oral and Suppository The main Read More …