Tag: Children myasthenia gravis

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Occurrence and treatment of myasthenia gravis

Autoantibodies Lead to Abnormal Transmission of Neuromuscular Junction The human body must rely on the normal neuromuscular junction transmission process (shown in the question figure) when completing each skeletal muscle contraction activity. The neuromuscular junction consists of (1) (presynaptic motor nerve endings), (2) (postsynaptic muscle cell membrane) and the synaptic gap between the two. When a motor command is transmitted from (1), It will activate ③ (synaptic vesicles) to release the chemical transmitter acetylcholine into synaptic spaces, and when acetylcholine moves to ② (postsynaptic muscle cell membrane) through the spaces, it will combine with ④ (acetylcholine receptor) above to further activate ⑤ (mitochondria in muscle cells), thus completing muscle contraction and executing movement instructions. The cause of myasthenia gravis lies Read More …

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Neonatal transient myasthenia gravis and childhood myasthenia gravis

Neonatal transient myasthenia gravis First of all, it is clear that myasthenia gravis is impossible for newborns delivered by non-myasthenia gravis mothers, because myasthenia gravis is an autoimmune disease and is related to the abnormality of the immune system. The immune system of newborns is not fully developed. How can myasthenia gravis occur? Therefore, myasthenia gravis does not need to be listed as the category of differential diagnosis for children with ptosis or abnormal eyeball movement immediately after delivery by healthy mothers. In theory, Neonatal transient myasthenia gravis exists, It can be caused by the anti-AChR antibody in the serum of the sick mother being transferred into the fetus through the placenta, The neonates showed difficulty in feeding, hypotonia, low Read More …

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Precautions for surgery and anesthesia in myasthenia gravis patients

Precautions for surgery in patients with myasthenia gravis As it is a rare disease, Many hospitals have to ask neurology consultation to determine the surgical indications and anesthesia methods after surgical treatment of myasthenia gravis patients with patients requiring surgery. In fact, the basic principle of clinical medicine is to [solve the main contradiction at present], If the patient’s surgery is imminent, Such as intestinal obstruction or spleen rupture, No matter what happened to the previous myasthenia gravis, emergency surgery is required. Even if the operation will aggravate myasthenia gravis, there is no need to worry about it. Because if the current surgical situation is not handled in time, it will endanger life. Therefore, emergency surgery for myasthenia gravis patients Read More …

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Precautions for Several Major Drugs in Myasthenia Gravis Patients

Statins and Myasthenia Gravis 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor) have that effect of reducing blood lipid and anti-inflammation, It can reduce the incidence of cerebrovascular diseases and coronary heart disease. In the past 10 years, the application of statins has increased significantly. Although most patients are generally well tolerated to statins, the drugs still have certain side effects, such as myalgia and rhabdomyolysis in severe cases. In theory, Statins may induce or aggravate myasthenia gravis symptoms, However, it is not caused by affecting the transmission of neuromuscular junctions. Pharmacological mechanism studies have found that, Statins can inhibit T cell activation, Inducing the transformation of helper T (Th) cells to Th2 cells, acting on B cells Read More …

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Is myasthenia gravis related to thymus what?

Thymus is located in the anterior mediastinum of the thoracic cavity behind the sternum. It is an important lymphoid organ of the human body. Its function is closely related to immunity. During the late embryo and birth, the human thymus weighs about 10-15g. With the growth of age, the thymus continues to develop and reaches puberty about 30-40g. After that, the thymus gradually degenerates, lymphocytes decrease, adipose tissue increases, and only 15g is reached in the elderly. According to incomplete clinical statistics, 90% of myasthenia gravis patients have thymus abnormalities, about 70% have thymus hyperplasia and 10-15% have thymoma. Some patients have obvious improvement of symptoms and obvious decrease of AChR antibody titer after thymectomy, which all indicate that thymus Read More …

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How to Improve the Quality of Life of Myasthenia Gravis Patients

What should be paid attention to in the diet of myasthenia gravis patients? Western medicine does not have too many restrictions on the diet of myasthenia gravis, while traditional Chinese medicine suggests eating less cold food, such as mustard, radish, mung bean, kelp, laver, watercress, day lily, sword flower, watermelon, balsam pear, etc. Eat more foods rich in high protein, such as chicken, duck, fish, lean meat, tofu, soybeans, eggs, vegetable protein and animal protein, as well as fresh vegetables and fruits, and pay attention to the digestibility of food. Should Myasthenia Gravis Patients Pay Attention to what in Their Life? This disease is a chronic disease with a long course of disease. Patients need to pay attention to the Read More …

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What about myasthenia gravis patients complicated with hyperthyroidism?

Hyperthyroidism and myasthenia gravis may occur successively or simultaneously, Myasthenia gravis can occur at various stages of hyperthyroidism. Both diseases are essentially autoimmune diseases. Just like the two enterprises funded by the same consortium, the source is the same, and there may be a common pathogenesis basis between the two: the cross-immune response of the common immune target organ-eye muscle and the common genetic background. All newly diagnosed myasthenia gravis patients should be screened for hyperthyroidism. If the two diseases occur at the same time, both should be considered in treatment. Generally speaking, there is no conflict in the treatment of the two diseases. If there is no medical contraindication, glucocorticoid therapy can be applied, thymectomy (for myasthenia gravis) can Read More …