Many relatives of leukemia patients, Refusing to donate hematopoietic stem cells because of doubts about donating them, It deprives patients of the chance to continue their lives. If everyone can know more about donating hematopoietic stem cells, Many patients will receive timely and effective treatment. Donating hematopoietic stem cells is actually what people often call [donating bone marrow]. In the past, in order to obtain hematopoietic stem cells, it was necessary to collect the bone marrow of donors (i.e. Those who donated hematopoietic stem cells), which was a painful process. Now, just like donating blood, Hematopoietic stem cells can be collected from blood vessels, There is no need for bone marrow puncture. For leukemia patients, The best source of hematopoietic stem cells is siblings of the same father and mother, The second is matched volunteers who are not related by blood. High-resolution confirmation of the process of donating hematopoietic stem cells: Before giving, The donor needs to be matched with the patient again, Determine whether the match was successful. Physical examination: The donor needs a physical examination, Must pass the physical examination, And confirmed their willingness to contribute, To enter the following process. Mobilize bone marrow: Hematopoietic stem cells mainly exist in bone marrow, The blood level is extremely low. [Mobilization] is to inject drugs subcutaneously into the donor. Promote bone marrow to produce more hematopoietic stem cells, And released into the blood circulation. This process takes 4-5 days. Blood routine tests are required every day during mobilization. Ensure that the donor’s white blood cells are within a safe range. Collection of stem cells: The venous blood of the donor is collected by the machine, After the machine collects the active ingredients, The rest of the components are returned to the donor body. Generally, it takes 3-5 hours to collect. 200 ~ 400 mL of whole blood were isolated each time, After several cycles, If the amount of hematopoietic stem cells collected is insufficient, It needs to be collected again the next day. After inspection, After determining the number of hematopoietic stem cells collected for transplantation, the staff will send the collected materials to the hospital where the patient is located in the shortest possible time and immediately deliver them to the patient. The donor can resume normal work and life after resting for 3-5 days without special supplements of health care products and nutrients. Is there any adverse reaction in what in donating hematopoietic stem cells? The process of donating hematopoietic stem cells is safe on the whole, and the probability of serious adverse events, such as thrombosis and spleen rupture, is only 1.1%. More than half of the donors with adverse reactions in the mobilization stage will feel bone soreness, which is caused by the rapid proliferation and differentiation of hematopoietic stem cells in bone marrow. A small number of donors will suffer from dryness-heat, excitement, fatigue and other conditions similar to common cold. Very few donors have allergy, left upper abdomen fullness (splenomegaly) and other phenomena. Most donors can tolerate these adverse reactions and only need symptomatic treatment, such as oral analgesic drugs, sleeping sedative drugs, etc. After the acquisition, These symptoms may disappear by themselves. Adverse reactions in the acquisition stage During the acquisition process, Donors may have numbness in their hands, feet and lips, This is caused by calcium deficiency. Oral calcium gluconate or intravenous calcium can relieve it. Proper drinking of high calcium milk before collection can also reduce the occurrence of this symptom. A few donors may suffer from dizziness, fatigue, palpitation and low blood pressure. This is due to light dehydration caused by the acquisition process. Slow down the acquisition speed, Or intravenous saline, The collection pipeline is a disposable sterile product, Therefore, the probability of blood contamination and infectious diseases is almost zero. After the collection process is completed, The blood routine test of the donor will have the phenomenon of high white blood cells and low platelets. Can return to normal after 1-2 weeks, does not affect normal life. At present, there is no long-term health damage caused by donation of hematopoietic stem cells. Those so-called statements that affect reproductive function and life span are even more nonsense. I hope everyone can face up to the donation of hematopoietic stem cells and rekindle the hope of life for leukemia patients!
