1. What is a blocking antibody? Is blocking antibody used in what?
(1) Blocking antibody is an antibody that exists in the blood of normal pregnant women and most normal pregnant women.
(2) Under normal circumstances, the fetus is conceived jointly by both parents and will carry some tissues (antigens) with the same genetic genes as the father. These are foreign bodies to the mother. The pregnant woman’s body will automatically reject these tissues, making the fetus unable to coexist peacefully with the mother, thus leading to abortion.
(3) The function of blocking antibodies is to [hide] these antigens from the father in the fetus, thus allowing the mother and the fetus to coexist peacefully and preventing abortion.
2. How is blocking antibody test done?
Blocking antibodies are present in serum and can be detected by routine fasting blood drawing.
3. Do you need to have a blocking antibody test in what?
(1) Spontaneous abortion for 2 or more times.
(2) The chromosome karyotype of husband and wife is normal.
(3) Excluding abnormal uterine structure and hormone level.
(4) There was no IgM positive in TORCH 4 items.
In case of the above situation, one can choose to check the serum blocking antibody to find out the cause of repeated abortion.
4. Are normal blocking antibodies positive? Are there many negative people?
No, generally only normal pregnant women and some normal menstrual parturients will appear positive for blocking antibodies.
There are many negative people, but it is only meaningful to check blocking antibodies after repeated abortions.
5. What Causes Negative Blocking Antibody Test Results?
There are many and complicated reasons, and its mechanism is not particularly clear.
Don’t think too much, the negative blocking antibody is not caused by you doing something wrong in what or eating something wrong in what.
6. Is there any what effect on the body caused by negative blocking antibody test results?
Negative blocking antibody may cause repeated abortion in the first trimester of pregnancy, except that there is no other obvious effect on the health of pregnant women.
7. Does negative blocking antibody affect pregnancy?
Negative blocking antibodies may lead to maternal rejection of the fetus, resulting in repeated early pregnancy abortions.
However, it should be noted that what is said here is only [possible], not [certain], so even if the test result is negative, don’t put too much pressure on yourself.
8. Do I need a blocking antibody test for an abortion?
Generally, there is only one abortion without checking the blocking antibody, because there are many reasons for abortion, not necessarily the negative blocking antibody.
9. The result of blocking antibody test is negative. Does this situation need treatment?
If the blocking antibody is found negative in the examination of women with recurrent abortion, treatment is required only after other causes of abortion are excluded, and will not be given priority in general.
10. How to treat negative blocking antibody?
At present, the treatment of negative blocking antibody is controversial, and sometimes the treatment effect is not good.
In the past, most cases will take active immunotherapy, that is, to pump the husband’s blood, separate lymphocytes, and then inject the husband’s lymphocytes into the wife’s subcutaneous, promote the wife’s body to produce blocking antibodies. Generally, this treatment should be repeated 3-4 times, 2 times before pregnancy, and 1-2 times after pregnancy.
11. It is said that there is some controversy over blocking antibody therapy. What talents must do this therapy? Is it OK not to do this treatment?
At present, there is indeed a dispute over the treatment of this. Some studies believe that active immunization cannot actually turn all blocking antibodies positive, so routine active immunotherapy is not recommended.
Patients with recurrent abortion should do a good job in relevant examinations. It is best to eliminate other causes of abortion first, then choose active immunotherapy to block negative antibody (which may be beneficial), and then try pregnancy.
12. If people with negative blocking antibodies are pregnant, is there any what that should pay special attention to?
There is nothing what should pay attention to.
Because the blocking antibody test is done before pregnancy, if the negative is still normal pregnancy, it can be treated as routine pregnancy.
In addition, even if active immunotherapy is required, it starts before pregnancy. If it is not done before pregnancy, active immunotherapy will not be carried out after pregnancy.
13. Is what Reproductive Immune Antibody Therapy? What talents need this treatment?
(1) The [reproductive immune antibody] in everyone’s mouth refers to the [blocking antibody], which is an antibody existing in the blood of normal pregnant women and most normal menstrual parturients.
Under normal circumstances, the fetus is conceived by both parents and will carry some tissues (antigens) with the same genetic genes as the father. These are foreign bodies to the mother. The pregnant woman’s body will automatically reject these tissues, making the fetus unable to coexist peacefully with the mother, thus leading to abortion.
The function of blocking antibodies is to [hide] these antigens from the father in the fetus, thus allowing the mother and the fetus to coexist peacefully and preventing abortion.
(2) If a woman with recurrent abortion is found to be negative for blocking antibody, treatment is required only after other causes of abortion are excluded.